Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pyridoxal phosphate (Vitamin B6 phosphate) 是维生素 B6 的活性形式,可抑制逆转录酶活性,用于研究迟发性运动障碍症。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 137 | 现货 | ||
50 mg | ¥ 198 | 现货 | ||
100 mg | ¥ 387 | 现货 | ||
200 mg | ¥ 431 | 现货 |
产品描述 | Pyridoxal phosphate (Vitamin B6 phosphate) is the active form of vitamin B6 and a coenzyme for many pyridoxal phosphate (PLP)-dependent enzymes. PLP is involved in numerous enzymatic transamination, decarboxylation and deamination reactions; it is necessary for the synthesis of amino acids and amino acid metabolites, and for the synthesis and/or catabolism of certain neurotransmitters, including the conversion of glutamate into gamma-aminobutyric acid (GABA) and levodopa into dopamine. PLP can be used as a dietary supplement in cases of vitamin B6 deficiency. Reduced levels of PLP in the brain can cause neurological dysfunction. |
体外活性 | Pyridoxal phosphate results in an immediate reduction in the rate of DNA synthesis. Pyridoxal 5′-phosphate severely inhibits the DNA Polymerase and RNase H. Conjugation to pyridoxal phosphate fully inhibits NEIL2. Pyridoxal phosphate-conjugated NEIL2 shows much lower activity than the intact enzyme over a wide range of enzyme/substrate ratios. After Pyridoxal phosphate conjugation, the ability of NEIL2 to bind the THF-ligand is completely lost. |
别名 | PLP, PAL-P, 磷酸吡哆醛, pyridoxal 5'-phosphate, Pyridoxyl phosphate, Pyridoxal 5′-phosphate, Vitamin B6 phosphate |
分子量 | 247.14 |
分子式 | C8H10NO6P |
CAS No. | 54-47-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (202.31 mM)
H2O: 20.23mM
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / H2O | 1 mM | 4.0463 mL | 20.2314 mL | 40.4629 mL | 101.1572 mL |
5 mM | 0.8093 mL | 4.0463 mL | 8.0926 mL | 20.2314 mL | |
10 mM | 0.4046 mL | 2.0231 mL | 4.0463 mL | 10.1157 mL | |
20 mM | 0.2023 mL | 1.0116 mL | 2.0231 mL | 5.0579 mL | |
DMSO | 50 mM | 0.0809 mL | 0.4046 mL | 0.8093 mL | 2.0231 mL |
100 mM | 0.0405 mL | 0.2023 mL | 0.4046 mL | 1.0116 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Pyridoxal phosphate 54-47-7 Metabolism Microbiology/Virology Reverse Transcriptase Endogenous Metabolite PLP Pyridoxal Pyridoxyl PAL-P 磷酸吡哆醛 pyridoxal 5'-phosphate inhibit Pyridoxyl phosphate Vitamin B6 Phosphate Pyridoxyl Phosphate Inhibitor Pyridoxal Phosphate Pyridoxal 5′-phosphate Vitamin B6 phosphate inhibitor